CyberinfraV1, Main, Exploration, bibRecord, 000C13

Computational Modeling and Real-Time Control of Patient-Specific Laser Treatment of Cancer

Identifieur interne : 000C13 ( Main/Exploration ); précédent : 000C12; suivant : 000C14

Computational Modeling and Real-Time Control of Patient-Specific Laser Treatment of Cancer

Auteurs : D. Fuentes [États-Unis] ; J. T. Oden [États-Unis] ; K. R. Diller [États-Unis] ; J. D. Hazle [États-Unis] ; A. Elliott [États-Unis] ; A. Shetty [États-Unis] ; R. J. Stafford [États-Unis]

Source :

Annals of biomedical engineering [ 0090-6964 ] ; 2009.

RBID : PMC:4064943

English descriptors

KwdEn :
- Algorithms, Animals, Biomedical Engineering (methods), Calibration, Computational Biology (methods), Computer Simulation, Computer Systems, Dogs, Feedback, Forecasting, Hot Temperature, Humans, Hyperthermia, Induced, Image Processing, Computer-Assisted, Laser Therapy, Magnetic Resonance Imaging (methods), Male, Models, Biological, Phantoms, Imaging, Prostatic Neoplasms (therapy), Reproducibility of Results, Software, Therapy, Computer-Assisted.
MESH :
- methods : Biomedical Engineering, Computational Biology, Magnetic Resonance Imaging.
- therapy : Prostatic Neoplasms.
- Algorithms, Animals, Calibration, Computer Simulation, Computer Systems, Dogs, Feedback, Forecasting, Hot Temperature, Humans, Hyperthermia, Induced, Image Processing, Computer-Assisted, Laser Therapy, Male, Models, Biological, Phantoms, Imaging, Reproducibility of Results, Software, Therapy, Computer-Assisted.

Abstract

An adaptive feedback control system is presented which employs a computational model of bioheat transfer in living tissue to guide, in real-time, laser treatments of prostate cancer monitored by magnetic resonance thermal imaging (MRTI). The system is built on what can be referred to as cyberinfrastructure - a complex structure of high-speed network, large-scale parallel computing devices, laser optics, imaging, visualizations, inverse-analysis algorithms, mesh generation, and control systems that guide laser therapy to optimally control the ablation of cancerous tissue. The computational system has been successfully tested on in-vivo, canine prostate. Over the course of an 18 minute laser induced thermal therapy (LITT) performed at M.D. Anderson Cancer Center (MDACC) in Houston, Texas, the computational models were calibrated to intra-operative real time thermal imaging treatment data and the calibrated models controlled the bioheat transfer to within 5°C of the predetermined treatment plan. The computational arena is in Austin, Texas and managed at the Institute for Computational Engineering and Sciences (ICES). The system is designed to control the bioheat transfer remotely while simultaneously providing real-time remote visualization of the on-going treatment. Post operative histology of the canine prostate reveal that the damage region was within the targeted 1.2cm diameter treatment objective.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064943

DOI: 10.1007/s10439-008-9631-8
PubMed: 19148754
PubMed Central: 4064943

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Computational Modeling and Real-Time Control of Patient-Specific Laser Treatment of Cancer</title>
<author><name sortKey="Fuentes, D" sort="Fuentes, D" uniqKey="Fuentes D" first="D." last="Fuentes">D. Fuentes</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin TX 78712, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin TX 78712</wicri:regionArea>
<orgName type="university">Université du Texas à Austin</orgName>
<placeName><settlement type="city">Austin (Texas)</settlement>
<region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Oden, J T" sort="Oden, J T" uniqKey="Oden J" first="J. T." last="Oden">J. T. Oden</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin TX 78712, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin TX 78712</wicri:regionArea>
<orgName type="university">Université du Texas à Austin</orgName>
<placeName><settlement type="city">Austin (Texas)</settlement>
<region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Diller, K R" sort="Diller, K R" uniqKey="Diller K" first="K. R." last="Diller">K. R. Diller</name>
<affiliation wicri:level="4"><nlm:aff id="A2"> Department of Biomedical Engineering, The University of Texas at Austin, Austin TX 78712, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Biomedical Engineering, The University of Texas at Austin, Austin TX 78712</wicri:regionArea>
<orgName type="university">Université du Texas à Austin</orgName>
<placeName><settlement type="city">Austin (Texas)</settlement>
<region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hazle, J D" sort="Hazle, J D" uniqKey="Hazle J" first="J. D." last="Hazle">J. D. Hazle</name>
<affiliation wicri:level="1"><nlm:aff id="A3"> University of Texas M.D. Anderson Cancer Center, Department of Imaging Physics, Houston TX 77030, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> University of Texas M.D. Anderson Cancer Center, Department of Imaging Physics, Houston TX 77030</wicri:regionArea>
<wicri:noRegion>Houston TX 77030</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Elliott, A" sort="Elliott, A" uniqKey="Elliott A" first="A." last="Elliott">A. Elliott</name>
<affiliation wicri:level="1"><nlm:aff id="A3"> University of Texas M.D. Anderson Cancer Center, Department of Imaging Physics, Houston TX 77030, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> University of Texas M.D. Anderson Cancer Center, Department of Imaging Physics, Houston TX 77030</wicri:regionArea>
<wicri:noRegion>Houston TX 77030</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shetty, A" sort="Shetty, A" uniqKey="Shetty A" first="A." last="Shetty">A. Shetty</name>
<affiliation wicri:level="1"><nlm:aff id="A3"> University of Texas M.D. Anderson Cancer Center, Department of Imaging Physics, Houston TX 77030, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> University of Texas M.D. Anderson Cancer Center, Department of Imaging Physics, Houston TX 77030</wicri:regionArea>
<wicri:noRegion>Houston TX 77030</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stafford, R J" sort="Stafford, R J" uniqKey="Stafford R" first="R. J." last="Stafford">R. J. Stafford</name>
<affiliation wicri:level="1"><nlm:aff id="A3"> University of Texas M.D. Anderson Cancer Center, Department of Imaging Physics, Houston TX 77030, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> University of Texas M.D. Anderson Cancer Center, Department of Imaging Physics, Houston TX 77030</wicri:regionArea>
<wicri:noRegion>Houston TX 77030</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">19148754</idno>
<idno type="pmc">4064943</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064943</idno>
<idno type="RBID">PMC:4064943</idno>
<idno type="doi">10.1007/s10439-008-9631-8</idno>
<date when="2009">2009</date>
<idno type="wicri:Area/Pmc/Corpus">000422</idno>
<idno type="wicri:Area/Pmc/Curation">000422</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000647</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">000069</idno>
<idno type="wicri:Area/PubMed/Curation">000069</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000069</idno>
<idno type="wicri:Area/Ncbi/Merge">000072</idno>
<idno type="wicri:Area/Ncbi/Curation">000072</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000072</idno>
<idno type="wicri:doubleKey">0090-6964:2009:Fuentes D:computational:modeling:and</idno>
<idno type="wicri:Area/Main/Merge">000C19</idno>
<idno type="wicri:Area/Main/Curation">000C13</idno>
<idno type="wicri:Area/Main/Exploration">000C13</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Computational Modeling and Real-Time Control of Patient-Specific Laser Treatment of Cancer</title>
<author><name sortKey="Fuentes, D" sort="Fuentes, D" uniqKey="Fuentes D" first="D." last="Fuentes">D. Fuentes</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin TX 78712, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin TX 78712</wicri:regionArea>
<orgName type="university">Université du Texas à Austin</orgName>
<placeName><settlement type="city">Austin (Texas)</settlement>
<region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Oden, J T" sort="Oden, J T" uniqKey="Oden J" first="J. T." last="Oden">J. T. Oden</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin TX 78712, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin TX 78712</wicri:regionArea>
<orgName type="university">Université du Texas à Austin</orgName>
<placeName><settlement type="city">Austin (Texas)</settlement>
<region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Diller, K R" sort="Diller, K R" uniqKey="Diller K" first="K. R." last="Diller">K. R. Diller</name>
<affiliation wicri:level="4"><nlm:aff id="A2"> Department of Biomedical Engineering, The University of Texas at Austin, Austin TX 78712, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Biomedical Engineering, The University of Texas at Austin, Austin TX 78712</wicri:regionArea>
<orgName type="university">Université du Texas à Austin</orgName>
<placeName><settlement type="city">Austin (Texas)</settlement>
<region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hazle, J D" sort="Hazle, J D" uniqKey="Hazle J" first="J. D." last="Hazle">J. D. Hazle</name>
<affiliation wicri:level="1"><nlm:aff id="A3"> University of Texas M.D. Anderson Cancer Center, Department of Imaging Physics, Houston TX 77030, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> University of Texas M.D. Anderson Cancer Center, Department of Imaging Physics, Houston TX 77030</wicri:regionArea>
<wicri:noRegion>Houston TX 77030</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Elliott, A" sort="Elliott, A" uniqKey="Elliott A" first="A." last="Elliott">A. Elliott</name>
<affiliation wicri:level="1"><nlm:aff id="A3"> University of Texas M.D. Anderson Cancer Center, Department of Imaging Physics, Houston TX 77030, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> University of Texas M.D. Anderson Cancer Center, Department of Imaging Physics, Houston TX 77030</wicri:regionArea>
<wicri:noRegion>Houston TX 77030</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shetty, A" sort="Shetty, A" uniqKey="Shetty A" first="A." last="Shetty">A. Shetty</name>
<affiliation wicri:level="1"><nlm:aff id="A3"> University of Texas M.D. Anderson Cancer Center, Department of Imaging Physics, Houston TX 77030, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> University of Texas M.D. Anderson Cancer Center, Department of Imaging Physics, Houston TX 77030</wicri:regionArea>
<wicri:noRegion>Houston TX 77030</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stafford, R J" sort="Stafford, R J" uniqKey="Stafford R" first="R. J." last="Stafford">R. J. Stafford</name>
<affiliation wicri:level="1"><nlm:aff id="A3"> University of Texas M.D. Anderson Cancer Center, Department of Imaging Physics, Houston TX 77030, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> University of Texas M.D. Anderson Cancer Center, Department of Imaging Physics, Houston TX 77030</wicri:regionArea>
<wicri:noRegion>Houston TX 77030</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Annals of biomedical engineering</title>
<idno type="ISSN">0090-6964</idno>
<idno type="eISSN">1573-9686</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Algorithms</term>
<term>Animals</term>
<term>Biomedical Engineering (methods)</term>
<term>Calibration</term>
<term>Computational Biology (methods)</term>
<term>Computer Simulation</term>
<term>Computer Systems</term>
<term>Dogs</term>
<term>Feedback</term>
<term>Forecasting</term>
<term>Hot Temperature</term>
<term>Humans</term>
<term>Hyperthermia, Induced</term>
<term>Image Processing, Computer-Assisted</term>
<term>Laser Therapy</term>
<term>Magnetic Resonance Imaging (methods)</term>
<term>Male</term>
<term>Models, Biological</term>
<term>Phantoms, Imaging</term>
<term>Prostatic Neoplasms (therapy)</term>
<term>Reproducibility of Results</term>
<term>Software</term>
<term>Therapy, Computer-Assisted</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Biomedical Engineering</term>
<term>Computational Biology</term>
<term>Magnetic Resonance Imaging</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Prostatic Neoplasms</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Algorithms</term>
<term>Animals</term>
<term>Calibration</term>
<term>Computer Simulation</term>
<term>Computer Systems</term>
<term>Dogs</term>
<term>Feedback</term>
<term>Forecasting</term>
<term>Hot Temperature</term>
<term>Humans</term>
<term>Hyperthermia, Induced</term>
<term>Image Processing, Computer-Assisted</term>
<term>Laser Therapy</term>
<term>Male</term>
<term>Models, Biological</term>
<term>Phantoms, Imaging</term>
<term>Reproducibility of Results</term>
<term>Software</term>
<term>Therapy, Computer-Assisted</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P3">An adaptive feedback control system is presented which employs a computational model of bioheat transfer in living tissue to guide, in real-time, laser treatments of prostate cancer monitored by magnetic resonance thermal imaging (MRTI). The system is built on what can be referred to as cyberinfrastructure - a complex structure of high-speed network, large-scale parallel computing devices, laser optics, imaging, visualizations, inverse-analysis algorithms, mesh generation, and control systems that guide laser therapy to optimally control the ablation of cancerous tissue. The computational system has been successfully tested on <italic>in-vivo</italic>
, canine prostate. Over the course of an 18 minute laser induced thermal therapy (LITT) performed at M.D. Anderson Cancer Center (MDACC) in Houston, Texas, the computational models were calibrated to intra-operative real time thermal imaging treatment data and the calibrated models controlled the bioheat transfer to within 5°C of the predetermined treatment plan. The computational arena is in Austin, Texas and managed at the Institute for Computational Engineering and Sciences (ICES). The system is designed to control the bioheat transfer remotely while simultaneously providing real-time remote visualization of the on-going treatment. Post operative histology of the canine prostate reveal that the damage region was within the targeted 1.2cm diameter treatment objective.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Texas</li>
</region>
<settlement><li>Austin (Texas)</li>
</settlement>
<orgName><li>Université du Texas à Austin</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Texas"><name sortKey="Fuentes, D" sort="Fuentes, D" uniqKey="Fuentes D" first="D." last="Fuentes">D. Fuentes</name>
</region>
<name sortKey="Diller, K R" sort="Diller, K R" uniqKey="Diller K" first="K. R." last="Diller">K. R. Diller</name>
<name sortKey="Elliott, A" sort="Elliott, A" uniqKey="Elliott A" first="A." last="Elliott">A. Elliott</name>
<name sortKey="Hazle, J D" sort="Hazle, J D" uniqKey="Hazle J" first="J. D." last="Hazle">J. D. Hazle</name>
<name sortKey="Oden, J T" sort="Oden, J T" uniqKey="Oden J" first="J. T." last="Oden">J. T. Oden</name>
<name sortKey="Shetty, A" sort="Shetty, A" uniqKey="Shetty A" first="A." last="Shetty">A. Shetty</name>
<name sortKey="Stafford, R J" sort="Stafford, R J" uniqKey="Stafford R" first="R. J." last="Stafford">R. J. Stafford</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Ticri/CIDE/explor/CyberinfraV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C13 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000C13 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Ticri/CIDE
   |area=    CyberinfraV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4064943
   |texte=   Computational Modeling and Real-Time Control of Patient-Specific Laser Treatment of Cancer
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:19148754" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a CyberinfraV1

This area was generated with Dilib version V0.6.25.
Data generation: Thu Oct 27 09:30:58 2016. Site generation: Sun Mar 10 23:08:40 2024

Serveur d'exploration Cyberinfrastructure

Computational Modeling and Real-Time Control of Patient-Specific Laser Treatment of Cancer

Computational Modeling and Real-Time Control of Patient-Specific Laser Treatment of Cancer

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration Cyberinfrastructure
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.